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What is Wharton's Jelly?

Wharton's jelly is a gelatinous substance found in the umbilical cord of mammals, including humans. It is named after the 17th-century English physician Thomas Wharton, who first described it. The umbilical cord is a vital structure that connects the developing fetus to the placenta during pregnancy, providing essential nutrients and oxygen to the fetus and facilitating the removal of waste products.

The main components of Wharton's jelly include a gelatinous matrix rich in hyaluronic acid and chondroitin sulfate. It also contains fibroblasts, which are cells that produce connective tissue proteins. Wharton's jelly has unique properties that make it an interesting subject of research, particularly in the field of regenerative medicine and tissue engineering.


Some of the key characteristics of Wharton's jelly include:

1.     Mesenchymal Stem Cells (MSCs): Wharton's jelly is a rich source of mesenchymal stem cells (MSCs), which are multipotent cells with the ability to differentiate into various cell types, such as bone, cartilage, and fat cells. These MSCs have shown promise in regenerative medicine applications.


2.     Immunomodulatory Properties: Research suggests that Wharton's jelly-derived MSCs possess immunomodulatory properties, meaning they can modulate the immune response. This property makes them potentially valuable for the treatment of inflammatory and autoimmune diseases.


3.     Low Immunogenicity: Wharton's jelly-derived MSCs may have lower immunogenicity compared to MSCs from other sources, making them potentially suitable for allogeneic transplantation (transplantation between individuals).

Ongoing research on Wharton's jelly focuses on various aspects, including:

  • Regenerative Medicine: Investigating the potential of Wharton's jelly-derived MSCs for tissue repair and regeneration in conditions such as spinal cord injury, heart disease, and musculoskeletal disorders.

  • Immunotherapy: Exploring the immunomodulatory properties of Wharton's jelly-derived MSCs for the treatment of autoimmune diseases and inflammatory conditions.

  • Clinical Trials: Conducting clinical trials to assess the safety and efficacy of Wharton's jelly-derived MSCs in different medical applications.

  • Biomaterial Development: Developing biomaterials based on Wharton's jelly components for use in tissue engineering and drug delivery.


It's important to note that research in this field is dynamic, and advancements are continually made. To access the latest information on Wharton's jelly research, checking recent scientific literature, clinical trial databases, and academic publications is recommended.

ClinicalTrials.Gov - Clinical Trials and Studies from around the World

Sourced by ChatGPT V3.5 on 12/19/2023: "describe wharton's jelly and what research is being done on it"

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